Posts Tagged mr spectroscopy
System Combines Capillary Electrophoresis And NMR Spectroscopy
By using micro-electromechanical systems (MEMS) technology, researchers at the University of Illinois have developed a chip-based analytical system that combines capillary electrophoresis and nuclear magnetic resonance (NMR) spectroscopy. Integrated microfluidic-NMR systems could have important applications in a wide variety of combinatorial chemistry areas — such as drug discovery — and might facilitate the development of desktop NMR spectrometers.
“Capillary electrophoresis and NMR spectroscopy have competing design goals, but by integrating them with MEMS technology we can maximize the performance of both systems,” said David Beebe, a professor of electrical and computer engineering and a researcher at the university’s Beckman Institute for Advanced Science and Technology. “By using very small channels and samples, we can do high-performance capillary electrophoresis separations. And by performing those separations multiple times, we can collect a large enough sample to do NMR spectroscopy.”
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MR Spectroscopy Helps Identify Cancerous Breast Tumors
Measuring the biochemical changes in breast tumors with magnetic resonance (MR) spectroscopy enables radiologists to more accurately distinguish benign tumors from cancerous ones, according to a study appearing in the August issue of the journal Radiology.
“Adding spectroscopy to breast MR examinations will not only reduce concern over possible missed cancers and unnecessary biopsy procedures, it may also improve the efficiency and quality of patient care,” said co-author Sina Meisamy, M.D., a postdoctoral fellow at the University of Minnesota Center for Magnetic Resonance Research in Minneapolis.
MR imaging of the breasts has a high rate of sensitivity (94 percent – 100 percent) for detecting tumors, but a variable rate of specificity (37 percent – 97 percent) for distinguishing malignant from benign tumors.
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MR Spectroscopy May Help Avoid Invasive Procedures And Treatments For Recurrent Brain Lesions
A clinical decision model which uses MR spectroscopy to help physicians differentiate between recurrent tumors and changes in the brain tissue due to radiation treatments, may help patients avoid invasive procedures and treatments, according to a study performed at the University of Michigan Health System in Ann Arbor, MI.
The study included 33 patients who had undergone radiation treatment for brain tumors and had MRI examinations that showed new lesions (either a recurrent tumor or radiation changes). Patients then underwent MR spectroscopy and ratios of three metabolites, choline (Cho), creatine (Cr) and n-acetylaspartate (NAA) were calculated. An ROC curve and prediction model was then created, which determined the post-test probability of a patient having a recurrent tumor. For the study, the final number of patients with recurrent tumors was 20 and those with post-radiation change were 13.
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MR Spectroscopy Significantly Reduces Need For Breast Biopsy
In a study featured in the June issue of Radiology, researchers found that imaging suspicious breast lesions with magnetic resonance (MR) spectroscopy reduced the need for biopsy by 58 percent. The investigators, from Memorial Sloan-Kettering Cancer Center in New York, discovered that with the addition of MR spectroscopy to their breast MR imaging (MRI) protocol, 23 of 40 suspicious lesions could have been spared biopsy, and none of the resultant cancers would have been missed.
“All cancers in this study were identified with MR spectroscopy. There were no false-negative results,” said Lia Bartella, M.D., lead investigator and assistant professor in the Department of Breast Imaging at Memorial Sloan-Kettering. “With the addition of MR spectroscopy to our breast MRI exam, we found that the number of biopsies recommended on the basis of MRI findings decreased significantly. These results should encourage more women to take this potentially life-saving test.”
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